As part of the Food and Drug Administration's campaign against food-borne illness, the agency has rolled out new rules for refrigeration and cleaning trucks and rail cars between shipments.
Refrigerated vehicles will have to be pre-cooled before loading and temperatures closely tracked while in transit.
The rules are part of the Food Safety Modernization Act, a sweeping law passed in 2010 to boost safety and sanitation throughout the food system.
"Consumers deserve a safe food supply and this final rule will help to ensure that all those involved in the farm-to-fork continuum are doing their part to ensure that the food products that arrive in our grocery stores are safe to eat," Michael R. Taylor, the FDA's deputy commissioner for foods and veterinary medicine, said in a press release.
Large businesses will have one year to get in line with the new regulations, and small businesses will be given two years to comply.