Sara Scalia scored 24 points, Mackenzie Holmes added 23 and No. 18 Indiana ran past Lipscomb 77-44 on Sunday.
Scalia made 5 of 7 3-pointers and added six rebounds with five assists. Holmes grabbed nine rebounds. No other player scored more than seven points for the Hoosiers (3-1).
Indiana hit 53% of its shots in the second quarter and outscored Lipscomb 21-6 for a 39-18 halftime lead. Indiana finished the half with a 15-2 scoring run in which Holmes scored seven points and Scalia added six. Lipscomb made just 2 of 10 shots in the second quarter.
Holmes scored six points in the first five minutes of the third quarter and the Hoosiers pushed their lead to 50-24. The lead reached 29 a couple of minutes later when Scalia hit a 3-pointer.
The Bisons closed to within 23 points early in the fourth but Indiana responded with a 10-2 run.
Molly Heard led the Bisons (3-2) with 14 points and eight rebounds.
Indiana plays No. 15 Tennessee on Thursday at the Fort Meyers Tip-Off.
