The Indiana State Department of Health reports four Hoosiers have died of the flu since the influenza season started in October, although the first flu death was reported in late December. Officials also say flu-like illnesses are increasing throughout the state.
Health officials say getting a flu shot is the most effective way to protect against the influenza virus.
"I hope any Hoosier who hasn't received a vaccine yet will consider getting one," State Health Commissioner Jerome Adams said in a statement.
Adams says it is especially important for healthcare workers and pregnant women to get the vaccine.
Officials say the influenza season typically peaks in January, but it could peak later. The flu vaccine takes about two weeks to become effective.